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La PDE5 è la fosfodiesterasi predominante nei vasi polmonari. L’inibizione della PDE5 da parte di tadalafil aumenta le concentrazioni della cGMP determinando un rilassamento della muscolatura liscia dei vasi polmonari e una vasodilatazione del letto vascolare polmonare.
Sildenafil was reclassified in New Zealand in 2014 so it could be purchased more than the counter from a pharmacist. It is believed this reduced product sales over the web and was safer as males can be referred for healthcare advice if appropriate.[119]
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